पराचा कावळा करायची,
शेवटी मुलगी ती मुलगी अन सून ती सून,
आईसुद्धा नाहक वहिनीचा द्वेष करू लागली,
मीनलला समाधान मिळायचं,
आई वडील अंथरुणाला खिळले तशी वहिनीने अपार सेवा केली,
मीनल मात्र संपत्तीत वाटा म्हणून प्रयत्न करू लागली,
फूस लावून अखेर अर्ध्याहून जास्त मालमत्ता तिने मिळवलीच,
आई वडील गेले,
तिने माहेरी फिरकून पाहिलं नाही,
भाऊ आणि वहिनी काटकसर करून संसार करत होते,
मीनलने मात्र सगळी हौस केली,
तिच्या नावावरची जमीन विकली,
मोठं घर घेतलं,
हळूहळू गाडी घेतली,
तिच्या नवऱ्याला तर सगळं आयतं मिळत होतं,
खुश होता तो,
पैशापुढे स्वाभिमान थिटा पडला,
उरलीसुरली सगळी मौज करत होती,
भाऊ अन वहिनी भेटायला आलेले तिला आवडत नसे,
लाज वाटायची तिला, कारण आता उच्चभ्रू सोसायटीत ती राहत होती,
एकदा त्या बायकांची पार्टी सुरू असतांना दादा वहिनी आले,
तिला वहिनीची ओळख करून द्यायला लाज वाटायची,
एकीने विचारलं,
ही कोण?
ही कुणी नाही..
कुणी नाही? झिरो आहे का?
हो झिरो आहे, झिरो म्हणजे कुणी नाही…हा हा हा…
बायकांमध्ये हशा पिकला,
वहिनीला रडू आलं…
ते परत गेले…
आपापल्या कामाला लागले,
भाऊ अन वहिनी आहे त्या जमिनीत शेती करत,
काबाडकष्ट करत,
दिवसभर राबत,
कितीतरी वेळा नुकसान होई,
पण कधी त्यावरून दोघांनी चिडचिड केली नाही,
कष्ट करत राहिले…
वहिनी हुशार होती,
नवनवीन प्रयोग करायची शेतीचे,
सेंद्रिय शेती, आवक, शेतमाल याची माहिती गोळा करे,
भावाला एकेक गोष्ट सांगून सगळं अंमलात आणे,
***
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How to Remove Laugh Lines?
How to Remove Laugh Lines?
Laughter is often associated with joy and happiness, but it can also leave behind
visible lines on the face known as “laugh lines.” These creases form due to repeated facial movements and skin aging.
Over time, your skin may lose elasticity, causing these lines to become more pronounced.
Whether you want to reduce them for a more youthful appearance or simply minimize their visibility, there
are several options available.
Understanding Laugh Lines
Laugh lines, also called facial creases or wrinkles, occur
when the skin loses its elasticity and begins to sag around
areas like the eyes, mouth, and cheeks. The constant movement
of facial muscles during laughing, smiling, or even talking
can contribute to these lines. They are a natural part of aging but can be
addressed through various treatments.
Treatment Options
There are multiple approaches to eliminate laugh lines, each with its own benefits and
potential outcomes. One popular method is using injectable fillers.
These fillers, such as Restylane or Juvederm, are injected beneath the skin to add volume
and lift the facial structure, smoothing out visible creases.
Another option is Botox, which works by temporarily freezing the muscles responsible for fine lines, preventing them from deepening.
Additionally, treatments like Thermage or laser therapy can target deeper layers of skin to promote collagen production and tighten skin tissue.
For a more physical approach, microdermabrasion can be used
to gently exfoliate the surface layer of skin, reducing
the appearance of lines.
Choosing the Right Approach
When considering which treatment is best for you, it’s important to evaluate your lifestyle and goals.
For instance, if you’re looking for a non-invasive option with temporary results, Botox or fillers might be ideal.
On the other hand, if you prefer a more long-term solution, surgical
procedures like a facelift could be a better fit.
Consulting with a qualified dermatologist or cosmetic surgeon can help you make an informed decision tailored to your specific needs.
Related Articles
For further reading, explore articles on facial rejuvenation techniques, anti-aging
solutions, and the latest advancements in skin care treatments.
These resources can provide additional insights into maintaining a youthful and refreshed appearance.
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Still, most women will find that Anavar is more well-tolerated in terms
of controlling the side effects. For girls who want to
use Winstrol, the oral form only is beneficial, and doses must be saved very low to keep away from virilization. Anavar is not probably the
most suppressive steroid, but your pure testosterone production is
prone to have taken successful. This could cause symptoms of low testosterone when your cycle ends,
together with lack of muscle and fat achieve. If you have
not any existing kidney problems, using low doses
and short cycles of Anavar is unlikely to cause kidney harm.
Still, if you use excessive doses and long
cycles, you will be placing your kidneys – and other organs – at nice threat of harm.
Anavar just isn’t sometimes known for its important strength-enhancing
properties compared to different anabolic steroids
like Anadrol or Dianabol. Whereas it does have some anabolic effects and might
contribute to modest strength features, its major focus
is on selling lean muscle mass and fat burning. Anadrol is extremely regarded for its potent
anabolic properties, making it some of the powerful steroids obtainable.
It is thought to promote vital muscle mass and
power positive aspects in a relatively quick interval. Due
to its effectiveness in selling muscle development, Anadrol
is often utilized in bulking cycles by bodybuilders and athletes.
If you’re seeking to enhance your athletic efficiency or construct
lean muscle mass, you might have heard of a preferred steroid called Anavar.
Anavar, also identified as Oxandrolone, is a synthetic hormone that mimics the consequences of testosterone in the
body.
Some will allow you to overcome the bulking points inherent with Anvarol
while others will help enhance its slicing abilities. Anvarol is like different
legal steroids because it might be stacked efficiently with other forms of legal options safely and effectively.
And while its muscle gains will be extra modest when compared to the
bulking you get when Anavar, they will be extra practical and sustainable after you quit.
Below, you’ll learn extra about the way to dose Anavar correctly and
the finest way to cycle it through your system.
In this fashion, you’ll have the power to take it and decrease your potential side effects safely.
After its release in 1964, it was promoted closely as a method of managing muscle-disorders and involuntary weight loss.
The examine discovered that people who frequently took Anavar would improve
their testosterone ranges and increase their metabolism.
However in most nations, it could only be bought on the black market, and Anavar is mostly priced higher than lots of different steroids.
In the Usa, it’s unlawful to purchase or use Anavar without a prescription from a doctor.
As expected, most critiques and experiences from actual people
utilizing Anavar are optimistic. Individuals report excellent outcomes for weight loss, chopping,
and preserving muscle tissue, which is where Anavar excels.
Anavar can contribute considerably to some lean positive aspects, however for
male users, it’s most unlikely to be a purpose for using this steroid.
This can probably lead to cardiovascular points such as coronary
heart illness or stroke. It is necessary to monitor levels of cholesterol whereas utilizing Anavar and take steps to maintain up a wholesome cardiovascular
system. I got interested in the chance of attempting “one thing” and started reading about
it. Anavar keeps being mentioned as a preferred entry-level
steroid for girls, due to it being the least virilising of them with the
fewest unwanted facet effects. And a few of the unwanted effects had been appealing, particularly the
potential of enhance in libido. The results on the temper described by different users was additionally
interesting to me.
Anavar is often found in efficiency based slicing cycles by its nature anavar bonds fairly properly to the androgen receptors and can promote dry muscle features without bloating and further bulking.
As A Result Of we’re utilizing steroids for performance enhancement and bodybuilding, the compounds are being
taken at doses much higher than in the occasion that they had
been used for medical functions. The larger your dosage, the larger
your threat of antagonistic well being results. Trenbolone and Anavar may be
stacked collectively throughout bulking or chopping cycles, resulting in considerable fats loss and tremendous positive aspects in muscle mass.
Anavar and Turinabol are thought of comparatively mild
compounds in the anabolic steroid household tree. Nonetheless, their benefits by means
of muscular hypertrophy and power are far from mild.
Before starting an Anavar cycle, it’s essential to consult with a
healthcare professional to determine the suitable dosage and to watch your progress all
through the cycle.
Like all AAS, Anavar will positively have an result on your recovery, dashing up tissue healing.
With its known advantages on collagen synthesis (after all, Anavar was initially developed to promote healing), it can reduce soreness and
ache post-workout. Anabolic steroids, similar to Anavar,
can increase the exercise and sensitivity of oral anticoagulants (blood thinners).
Peliosis Hepatis is a condition during which blood-filled
cysts present in the liver and generally the spleen because of Anavar utilization. The cysts can develop and accumulate within the liver, replacing
normal hepatocytes that can result in liver
failure and dysfunction. Anavar is an oral medication that is absorbed across the
gastrointestinal tract. Peak serum concentrations of
Anavar occur inside 1 hour after ingestion.
Power enhancements can be the first thing you notice whenever
you begin a Winstrol cycle. This fast-acting steroid will considerably
increase energy, providing the baseline for all the other performance enhancement advantages, significantly power and velocity.
You aren’t placing hormones directly into the physique with Win-Max;
the consequences won’t be as instantaneous or as powerful.
If you’re not a fan of injecting, then that alone could be enough to
have you ever looking at Winstrol oral instead, no matter
a few of these advantages of Winstrol Depot. Anvarol from CrazyBulk
is a authorized steroid various that has been developed to imitate the consequences of Anavar oxandrolone—but without damaging you or your financial institution stability.
Long-term protection from hair loss and reduced incidence of
sure kinds of pores and skin cancer (including ovarian cancer).
Moreover, it seems to be effective at decreasing
fats storage within the muscle tissue.
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In addition to the previous nickname ‘Var,’ that is nonetheless the name by which it’s most well known. In addition, Anvarol is straightforward to acquire and authorized to use
and not using a prescription. It can be bought on-line without the necessity for a physician’s approval or a
risky black market purchase.
It is essential to prioritize health and adhere to
really helpful dosages and protocols to attenuate potential unwanted facet effects and guarantee a
accountable method to efficiency enhancement. Women typically require a
decrease dose in comparison with males as a outcome of
their biological make-up. While the best dosage can differ based mostly on the individual’s body traits and fitness goals, a commonly really helpful dose
of anavar for women is between 5 to 10 milligrams per day.
This range is considered delicate yet effective enough to ship noticeable energy positive aspects and improved muscle definition with out excessive
side effects. A well-liked cycle involves girls customers taking Anavar
over a interval of 6 to eight weeks. Throughout this time, a dose of 5 to 10 milligrams per
day is often used.
All things being even, the more steroid cycles you run (and the larger amount of muscle mass you build and carry), the upper the dosages required in your subsequent cycle to elicit related gains.
Of course, this isn’t linear, and there are a big selection of factors that may affect this, however sometimes
as your steroid-taking expertise will increase, the necessity for greater dosages may also enhance.
So, if you’ve taken steroids earlier than, your dose of Anavar will must be higher than someone with zero steroid
experience. Trenbolone and Anavar may be stacked
collectively throughout bulking or cutting cycles, resulting in appreciable fats
loss and tremendous gains in muscle mass. However, as a result
of presence of trenbolone, we think about this to be a harsh
cycle and not appropriate for novices. Men who use anabolic steroids are often involved with increased aggression and mood modifications
as a facet impact, but HGH works differently from testosterone.
HGH itself may help enhance mental well-being and temper when used at smart doses.
The dosage of Anavar for muscle achieve can vary something from 20mg per
day to 100mg per day. Although women have a fraction of testosterone compared to males, it stays an essential hormone of their body chemistry.
Clenbuterol is a beta-2 agonist and has been utilized in drugs
as an anti-asthma drug.
Get the drug information and choice help you want,
together with TRUE Day By Day Updates™ together with every single
day including weekends and holidays. It’s additionally essential that you
don’t take this treatment if you’re pregnant.
This treatment could cause start defects and probably harm
your unborn youngster. You ought to make certain that you
are utilizing efficient birth control when taking this treatment and let your doctor know instantly
should you become pregnant while on this treatment.
During your oxandrolone treatment, you will need to get regular
blood and urine tests.
This is commonly accompanied by enhanced vascularity, and an total
tighter look. One commonly used trick to successfully scale back the worth of Anavar
is to take it with 200ml of grapefruit juice as an alternative of water.
There is an enzyme in the intestines and liver, generally recognized
as CYP3A4, which plays a role in breaking down foreign molecules within the physique.
Anavar for ladies is commonly faked on the black market,
with folks showing positive effects with out really having
used the product. Thus girls should order a testing package before they take anavar, or any comparable controlled substance.
(Personally, I’ll use the drug for no much less than 6–8 weeks.) Spreading out my dose throughout the
day at the identical pace each time (20 mg/20 mg/20 mg) yields the greatest
outcomes for me. Use 50 mg of clomid every day in the course of the post-cycle remedy phase, and
you must recuperate rapidly. As A Outcome Of bodybuilding ranges of Oxandrolone result in a quite high suppression of testosterone, it’s always beneficial that
men stack Anavar with Testosterone when utilizing this steroid.
This is as a end result of of the reality that bodybuilding-relevant doses of Oxandrolone induce a relatively substantial reduction of
testosterone. Nevertheless, it’s predicted that this period of restoration can be fairly short (a few of weeks)
earlier than natural testosterone ranges return to regular.
400mg weekly of Trenbolone Acetate for eight weeks will compound considerably on the outcomes
of Anavar. Anavar, or oxandrolone, is likely one of
the most commonly used anabolic steroids, with both men and
women biking it. Some bodybuilders make the
most of Anavar all year spherical, similar to testosterone replacement therapy (TRT).
Nevertheless, this isn’t beneficial as a outcome of excessive hepatic and renal
toxicity.
AIs could also be used as an alternative to prevent gynecomastia, providing protection from
excessive estrogen and progesterone. Thus, they want to only
be integrated if users begin to observe early indicators
of gynecomastia. Gynecomastia is a possibility for genetically
delicate users because of testosterone aromatizing and due to this fact being an estrogenic
compound. This testosterone cycle for beginners, despite being cautiously dosed, is prone to produce important will increase in muscular size and
strength. In 1935, testosterone grew to become
the first-ever anabolic steroid, being extracted from a bull’s testicles.
Before taking exogenous testosterone, consult a doctor and be
cautious of potential unwanted effects. Evidence exhibits that increasing testosterone
levels can do a lot more on your well being and quality of life than just allow
you to do higher within the fitness center. The first three have half-lives of 108, 168–216, and 192–240 hours, respectively.
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El signo más característico es un aumento dramático y rápido
de la masa corporal exageradamente. Si los consumidores entrenan con pesas y comen una dieta
rica en calorías y rica en proteínas mientras están consumiendo los esteroides anabolizantes, aumenta tanto
la fuerza como la masa muscular. Los incrementos en los niveles de energía y los niveles
de la libido (en hombres) pueden tener lugar, pero son más difíciles de identificar.
Las hormonas masculinas, principalmente la testosterona, son parcialmente responsables
de los tremendos cambios que ocurren durante la pubertad y la adolescencia.
Los efectos androgénicos incluyen cambios en las características sexuales primarias y secundarias.
Esto incluye crecimiento del pene y testículos, cambios en la voz,
crecimiento del vello en la cara, axilas y áreas genitales e incrementos en la agresividad.
La mayor diferencia en el tamaño de las fibras musculares entre los usuarios de AAS y los
no usuarios se observó en las fibras musculares de tipo I del vasto
lateral y el músculo trapecio como resultado de la autoadministración de AAS
a largo plazo. Después de la suspensión del fármaco, los efectos desaparecen lentamente, pero
pueden persistir durante más de 6 a 12 semanas después de suspender el uso de AAS.
Las hormonas peptídicas solubles en agua no pueden penetrar la membrana de las células grasas y solo afectan indirectamente al núcleo de las células
diana a través de su interacción con los receptores de la superficie celular.
Sin embargo, como hormonas liposolubles, los AAS son permeables a la membrana
e influyen en el núcleo de las células por acción directa.
La acción farmacodinámica de AAS comienza cuando la hormona exógena penetra la
membrana de la célula diana y se une a un receptor de andrógenos (AR) ubicado en el citoplasma de esa célula.
El grado de virilización dependerá de la sustancia, la duración en el consumo y la respuesta del individuo.
Los cambios en la composición corporal durante el consumo de esteroides son similares a aquellos experimentados por los
jóvenes durante la pubertad. En adición a los efectos secundarios
irreversibles tales como engrosamiento de la voz,
incremento del vello facial y clítoris hipertrofiado, algunos de
los efectos hipertróficos de los esteroides
anabólicos sobre los músculos esqueléticos en las mujeres pueden ser permanentes.
Señales de testosterona no solo a través del AR nuclear,
sino también a través de mAR, incluidos ZIP9 y GPRC6A.
Menos del 15% de los competidores estaban utilizando más de
dos esteroides simultáneamente. Para el atleta que mejora el rendimiento masculino, una dosificación de mg por día proporcionará una mejora atlética pero la mayoría encontrará que mg por día es
mucho más eficiente. De los posibles efectos secundarios del Anavar, el más preocupante rodeará el colesterol.
La hormona Oxandrolona es conocida por suprimir el colesterol HDL, así como también por aumentar el colesterol LDL.
Las dosis terapéuticas masculinas estándar pueden suprimir el colesterol HDL en hasta un 30%
con dosis de rendimiento que suprimen el HDL hasta en un 50%.
La naturaleza androgénica aunque leve también puede promover síntomas de virilización en las mujeres.
Los síntomas de virilización incluyen crecimiento del
vello corporal, profundización de las cuerdas vocales y agrandamiento del clítoris.
La falta de 5α-reductasa en el testículo, podría explicar por
qué los inhibidores de esta enzima no tienen un marcado efecto en la espermatogénesis22; por
consiguiente, la testosterona no es reducida a DHT.
Esta es más potente ligada al RA que aquella, por lo que en el compartimiento tubular,
en ausencia de DHT y para mantener la expresión del RA, será necesario mantener niveles altos de testosterona que se encontrará principalmente ligada a la ABP producida por las células de Sertoli23.
Los túbulos seminíferos están expuestos a concentraciones de testosterona de 25 a 100 veces mayor que los niveles circulantes.
Los esteroides deben ser prescritos con la dosis mínima efectiva y por el
menor tiempo posible para evitar efectos secundarios. Entre los usos terapéuticos de los esteroides se encuentran el tratamiento
de enfermedades autoinmunes, procesos inflamatorios y alergias severas.
Estas sustancias pueden ayudar a reducir la inflamación y controlar respuestas inmunitarias desreguladas, mejorando
así la calidad de vida de los pacientes.
Si bien muchos esteroides anabólicos tienen una potencia androgénica disminuida en comparación con la potencia anabólica, no existe un esteroide anabólico que sea exclusivamente anabólico y, por lo tanto, todos los esteroides anabólicos
retienen al menos algún grado de androgenicidad. (Del mismo modo, todos los “andrógenos” son inherentemente anabólicos).De hecho, probablemente
no sea posible disociar completamente los efectos anabólicos de los efectos androgénicos,
ya que ambos tipos de efectos están mediados por el
mismo receptor de señalización, el AR. Como tal, la distinción entre los términos esteroide anabólico y andrógeno es cuestionable, y esta es la
base del término revisado y más reciente esteroide anabólico-androgénico (AAS).
Los derivados de testosterona no alquilados en 17α, como
la testosterona misma, la DHT y la nandrolona, tienen una biodisponibilidad oral deficiente debido al extenso metabolismo hepático de primer paso y, por lo tanto, no son activos por vía oral.
Una excepción es el undecanoato de testosterona de éster de cadena muy larga,
que es activo por vía oral, aunque con una biodisponibilidad oral muy baja (aproximadamente 3%).
A diferencia de la mayoría de los otros AAS, los derivados de testosterona 17α-alquilados muestran resistencia al metabolismo debido al impedimento estérico y son activos por vía oral,
aunque también pueden esterificarse y administrarse mediante
inyección intramuscular. El desarrollo del tejido mamario en los hombres, una condición llamada ginecomastia (que generalmente es causada por altos niveles
de estradiol circulante), puede surgir debido a una mayor conversión de testosterona
en estradiol por la enzima aromatasa.
Anavar es el agente que necesita debido a los hechos discutidos anteriormente con respecto a sus efectos.
Si bien el uso y abuso de esteroides anabólicos ha estado siempre relacionado con el mundo del deporte de alta competición, desde hace mucho tiempo están prohibidos en el deporte profesional ya que
se están considerados como dopaje. El uso
entre mujeres sucede, pero de forma menos asidua,
a pesar de que los efectos de estas sustancias se pueden producir tanto en hombres como en mujeres.
No obstante, los datos que respaldan utilizar esteroides anabólicos para las patologías anteriormente
mencionados son escasos.
Los corticoides, principalmente cuando son tomados por vía oral, pueden hacer que el cuerpo retenga más sal, la cual, en grandes cantidades en el organismo, aumenta la retención de
líquidos, lo que promueve el aumento del peso.
A las dosis utilizadas en el tratamiento de patologías, los
esteroides anabolizantes causan pocos problemas. Los profesionales de la salud tienen el papel crucial
de educar a los pacientes sobre el uso adecuado de los esteroides y prevenir los posibles efectos adversos.
De 53 culturistas que usaron EAA, 27 (51 %) informaron trastornos
del estado de ánimo no especificados. Generalmente, se debe utilizar el esteroide eficaz más débil; sin embargo,
algunos médicos pueden optar por utilizar un esteroide tópico más potente inicialmente durante
los primeros días. Es común que los atletas que hacen ejercicio durante mucho tiempo utilicen un tipo de eritropoyetina fabricada en un laboratorio, llamada epoetina.
La androstenodiona puede dañar el corazón y los vasos sanguíneos de
cualquier persona que se la administre, lo que aumenta el riesgo de tener un ataque cardíaco, un problema grave que ocurre cuando el corazón no recibe suficiente sangre.
También aumenta el riesgo de tener un accidente cerebrovascular,
una afección en la que el cerebro no recibe suficiente oxígeno.
El abuso de los esteroides se ha difundido a tal extremo en el atletismo, que
afecta el resultado de las competencias deportivas.
Las hormonas esteroideas trabajan por estimulación de moléculas receptoras en las células musculares, quienes afectan genes específicos para producir proteínas (Figura 1).
También afectan la tasa de activación de los sistemas enzimáticos
involucrados en el metabolismo proteico, por esta razón incrementan la síntesis proteica e inhiben la proteolisis (llamado efecto anti-catabólico).
Pueden ser consumidos en diferentes formatos, en pastilla, aplicado
en gel o crema o inyectado directamente en el músculo.
Por norma general, los esteroides anabólicos cuentan con fluoximesterona y nandrolona.
References:
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